Entry 2 senses · 2 variants Webster, 1913 Vesiculate · Ve·sic·u·late · IPA a. v. t. 01 a. Bladdery; full of, or covered with, bladders; vesicular. 1. Bladdery; full of, or covered with, bladders; vesicular. 02 v. t. To form vesicles in, as lava. 1. To form vesicles in, as lava.