Entry 1 sense Webster, 1913 Urethra /yẽrˌ-ēth'-rə/ · U·re·thra · IPA /jʊˈɹiθɹə/ 01 n. The canal by which the urine is conducted from the bladder and discharged. 1. The canal by which the urine is conducted from the bladder and discharged.(Anat.)