Entry 2 senses · 2 variants Webster, 1913 Uptown /ŭp'-toun'/ · Up·town · IPA /ˈʌptaʊn/ adv. a. 01 adv. To or in the upper part of a town; as, to go uptown. 1. To or in the upper part of a town; as, to go uptown.[Colloq. U. S.] 02 a. Situated in, or belonging to, the upper part of a town or city; as, a uptown street, shop, etc.; uptown society. 1. Situated in, or belonging to, the upper part of a town or city; as, a uptown street, shop, etc.; uptown society.[Colloq. U. S.]