Entry 1 sense Webster, 1913 Unshackle /ən-shăk'-əl/ · Un·shac·kle · IPA /ənʃˈækəl/ 01 v. t. To loose from shackles or bonds; to set free from restraint; to unfetter. 1. To loose from shackles or bonds; to set free from restraint; to unfetter.