Entry 1 sense Webster, 1913 Staphyloma /(-lō"mȧ)/ · Staph·y·lo·ma · IPA 01 n. A protrusion of any part of the globe of the eye; as, a staphyloma of the cornea. 1. A protrusion of any part of the globe of the eye; as, a staphyloma of the cornea.(Med.)