Entry 2 senses · 2 variants Webster, 1913 Splenetic · Splen·e·tic · IPA /spləˈnɛtɪk/ a. n. 01 a. Affected with spleen; malicious; spiteful; peevish; fretful. 1. Affected with spleen; malicious; spiteful; peevish; fretful. “You humor me when I am sick; Why not when I am splenetic?” — Pope. Syn. Morese; gloomy; sullen; peevish; fretful. 02 n. A person affected with spleen. 1. A person affected with spleen.