Entry 2 senses · 2 variants Webster, 1913 Southpaw /south'-pouˌ/ · South·paw · IPA /ˈsaʊθˌpɔː/ a. n. 01 a. Using the left hand in pitching; said of a pitcher. 1. Using the left hand in pitching; said of a pitcher.(Baseball) [Cant] 02 n. A pitcher who pitches with the left hand. 1. A pitcher who pitches with the left hand.[Cant]