Entry 1 sense Webster, 1913 Souffle /so͞of-lā'/ · Souf·fle · IPA /suːflˈeɪ/ 01 n. A murmuring or blowing sound; as, the uterine souffle heard over the pregnant uterus. 1. A murmuring or blowing sound; as, the uterine souffle heard over the pregnant uterus.(Med.)