Entry 1 sense Webster, 1913 Sclerotome /(sklĕr"ō̇*tōm [or] sklēr"ō̇*tōm)/ · Scler·o·tome · IPA 01 n. One of the bony, cartilaginous, or membranous partitions which separate the myotomes. 1. One of the bony, cartilaginous, or membranous partitions which separate the myotomes.(Zool.)