Entry 2 senses · 2 variants Webster, 1913 Pliocene /plī'-əs-ēnˌ/ · Pli·o·cene · IPA /ˈplaɪəsiːn/ a. n. 01 a. Of, pertaining to, or characterizing, the most recent division of the Tertiary age. 1. Of, pertaining to, or characterizing, the most recent division of the Tertiary age.(Geol.) 02 n. The Pliocene period or deposits. 1. The Pliocene period or deposits.(Geol.)