Entry 2 senses Webster, 1913 Perspiration /pẽrsˌ-pẽr-āsh'-ən/ · Per·spi·ra·tion · IPA /ˌpɝspəˈɹeɪʃən/ 01 n. The act or process of perspiring. 1. The act or process of perspiring. 2. That which is excreted through the skin; sweat.