Entry 3 senses · 2 variants Webster, 1913 Mistrust /mĭs-trŭst'/ · Mis·trust · IPA /mɪsˈtɹʌst/ n. v. t. 01 n. Want of confidence or trust; suspicion; distrust. 1. Want of confidence or trust; suspicion; distrust. 02 v. t. To regard with jealousy or suspicion; to suspect; to doubt the integrity of; to distrust. 1. To regard with jealousy or suspicion; to suspect; to doubt the integrity of; to distrust. “I will never mistrust my wife again.” — Shak. 2. To forebode as near, or likely to occur; to surmise. “By a divine instinct, men's minds mistrust Ensuing dangers.” — Shak.