Entry 2 senses · 2 variants Webster, 1913 Misguide /mĭs-gīd'/ · Mis·guide · IPA /mɪsɡˈaɪd/ v. t. n. 01 v. t. To guide wrongly; to lead astray; as, to misguide the understanding. 1. To guide wrongly; to lead astray; as, to misguide the understanding. 02 n. Misguidance; error. 1. Misguidance; error.[Obs.]