Entry 1 sense Webster, 1913 Metabolite /mət-ăb'-əl-ītˌ/ · Me·tab·o·lite · IPA /mɪˈtæbəlaɪt/ 01 n. A product of metabolism; a substance produced by metabolic action, as urea. 1. A product of metabolism; a substance produced by metabolic action, as urea.(Physiol Chem.)