Entry 1 sense Webster, 1913 Meddlesome /mĕd'-əl-səm/ · Med·dle·some · IPA /ˈmɛdəlsəm/ 01 a. Given to meddling; apt to interpose in the affairs of others; officiously intrusive. 1. Given to meddling; apt to interpose in the affairs of others; officiously intrusive.