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Entry 1 sense Webster, 1913

Jamestown weed

/jām'-ztounˌ wēd/ · James·town· weed · IPA
01 The poisonous thorn apple or stramonium (Datura stramonium), a rank weed early noticed at Jamestown, Virginia. See Datura.
  1. 1.
    The poisonous thorn apple or stramonium (Datura stramonium), a rank weed early noticed at Jamestown, Virginia. See Datura.(Bot.) See: Datura