Entry 1 sense Webster, 1913 Interplay /ĭn'-tẽrp-lāˌ/ · In·ter·play · IPA /ˈɪn.tə(ɹ)ˌpleɪ/ 01 n. Mutual action or influence; interaction; as, the interplay of affection. 1. Mutual action or influence; interaction; as, the interplay of affection.