Entry 1 sense Webster, 1913 Hypospadias · Hy·po·spa·di·as · IPA /ˌhaɪ.pəˈspeɪ.di.əs/ 01 n. A deformity of the penis, in which the urethra opens upon its under surface. 1. A deformity of the penis, in which the urethra opens upon its under surface.(Med.)