Entry 1 sense Webster, 1913 Hypertrophic /hīpˌ-ẽrt-rōf'-ĭk/ · Hy·per·troph·ic · IPA /hʌɪpəˈtɹɒfɪk/ 01 a. Of or pertaining to hypertrophy; affected with, or tending to, hypertrophy. 1. Of or pertaining to hypertrophy; affected with, or tending to, hypertrophy.(Med. & Biol.)