Entry 1 sense Webster, 1913 Hecatomb · Hec·a·tomb · IPA /ˈhɛkətoʊm/ 01 n. A sacrifice of a hundred oxen or cattle at the same time; hence, the sacrifice or slaughter of any large number of victims. 1. A sacrifice of a hundred oxen or cattle at the same time; hence, the sacrifice or slaughter of any large number of victims.(Antiq.) “Slaughtered hecatombs around them bleed.” — Addison. “More than a human hecatomb.” — Byron.