Entry 2 senses · 2 variants Webster, 1913 Half-breed /(-brēd`)/ · Half·-breed · IPA a. n. 01 a. Half-blooded. 1. Half-blooded. 02 n. A person who is half-blooded; the offspring of parents of different races, especially of the American Indian and the white race. 1. A person who is half-blooded; the offspring of parents of different races, especially of the American Indian and the white race.