Entry 1 sense Webster, 1913 Ghettoize /gĕt'-ō-īzˌ/ · Ghet·to·ize · IPA /ˈɡɛtoʊaɪz/ 01 v. t. to form into a ghetto; to isolate (people) as though into a ghetto. 1. to form into a ghetto; to isolate (people) as though into a ghetto.