Entry 1 sense Webster, 1913 Domestication /dəm-ĕsˌ-tək-āsh'-ən/ · Do·mes·ti·ca·tion · IPA /dəmˌɛstəkˈeɪʃən/ 01 n. The act of domesticating, or accustoming to home; the action of taming wild animals. 1. The act of domesticating, or accustoming to home; the action of taming wild animals.