Entry 4 senses · 3 variants Webster, 1913 Disinterest /dĭs-ĭn'-tẽr-əst/ · Dis·in·ter·est · IPA /dɪsˈɪntɹɛst/ p. a. n. v. t. 01 p. a. Disinterested. 1. Disinterested.[Obs.] “The measures they shall walk by shall be disinterest and even.” — Jer. Taylor. 02 n. What is contrary to interest or advantage; disadvantage. 1. What is contrary to interest or advantage; disadvantage.[Obs.] 2. Indifference to profit; want of regard to private advantage; disinterestedness.[Obs.] 03 v. t. To divest of interest or interested motives. 1. To divest of interest or interested motives.[Obs.]