Entry 1 sense Webster, 1913 Desiccation /dĕsˌ-ək-āsh'-ən/ · Des·ic·ca·tion · IPA /ˌdɛsɪˈkeɪʃən/ 01 n. The act of desiccating, or the state of being desiccated. 1. The act of desiccating, or the state of being desiccated.