Entry 1 sense Webster, 1913 Depuration · Dep·u·ra·tion · IPA /dɛpjʊˈɹeɪʃən/ 01 n. The act or process of depurating or freeing from foreign or impure matter, as a liquid or wound. 1. The act or process of depurating or freeing from foreign or impure matter, as a liquid or wound.