Entry 1 sense Webster, 1913 Defibrinate · De·fi·bri·nate · IPA /dɪˈfaɪbɹɪneɪt/ 01 v. t. To deprive of fibrin, as fresh blood or lymph by stirring with twigs. 1. To deprive of fibrin, as fresh blood or lymph by stirring with twigs.