Entry 1 sense Webster, 1913 defenestrate /(dē̇*fĕn"ĕs*trāt)/ · de·fen·es·trate · IPA /dəˈfɛnɪstɹeɪt/ 01 v. t. to throw (something or someone) out of a window. 1. to throw (something or someone) out of a window.