Entry 1 sense Webster, 1913 Conflagration /känˌ-fləg-rāsh'-ən/ · Con·fla·gra·tion · IPA /ˌkɒnfləˈɡɹeɪʃən/ 01 n. A fire extending to many objects, or over a large space; a general burning. 1. A fire extending to many objects, or over a large space; a general burning. “Till one wide conflagration swallows all.” — Pope.