Entry 1 sense Webster, 1913 Bothersome /bŏʹthərsəm/ · Both·er·some · IPA /ˈbɔðəsəm/ 01 a. Vexatious; causing bother; causing trouble or perplexity; troublesome. 1. Vexatious; causing bother; causing trouble or perplexity; troublesome.