Entry 1 sense Webster, 1913 Archenemy /är'-chĕn'-əm-ē/ · Arch·en·e·my · IPA /ˈɑrtʃˈɛnəmiː/ 01 n. A principal enemy. Specifically, Satan, the grand adversary of mankind. 1. A principal enemy. Specifically, Satan, the grand adversary of mankind.